Each Kleenex® Anti-Viral tissue has three soft layers, including a moisture-activated middle layer that kills 99.9% of cold and flu viruses in the tissue within 15 minutes. It's virucidal against Rhinoviruses Type 1A and 2 (rhinoviruses are the leading cause of the common cold), Influenza A and B (causes of the flu), Respiratory Syncytial Virus (RSV–the leading cause of lower respiratory infection in children). Each box comes with tissues that feature small blue dots on the interior layer, which signal they're anti-viral. Buy in bulk, so you won't run out!